What is a severe reaction that can occur with sulfonamides?

Stevens-Johnson syndrome is a severe and potentially life-threatening condition that can occur as a reaction to sulfonamides. It is characterized by extensive skin damage, mucosal involvement, and systemic symptoms following the administration of sulfonamide drugs. The condition involves a significant immune-mediated response leading to the detachment of the epidermis from the underlying dermis.

Recognizing Stevens-Johnson syndrome is critical because it requires immediate medical intervention, including the discontinuation of the offending drug and supportive care. While some of the other reactions listed can occur with sulfonamides, such as allergic responses that might lead to anaphylactic shock or hematological disorders, Stevens-Johnson syndrome is particularly noted for its severity and associated morbidity.