What is the main action of HMG-CoA reductase inhibitors?

The main action of HMG-CoA reductase inhibitors is to inhibit cholesterol production. These medications, commonly known as statins, work by blocking the enzyme HMG-CoA reductase, which plays a crucial role in the biosynthesis of cholesterol in the liver. By doing so, they effectively lower the levels of low-density lipoprotein (LDL) cholesterol in the bloodstream, which can help reduce the risk of cardiovascular diseases, such as heart attacks and strokes.

The inhibition of cholesterol production not only lowers LDL cholesterol but can also result in a modest increase in high-density lipoprotein (HDL) cholesterol and a decrease in triglycerides. This mechanism is fundamental in managing patients who are at risk for atherosclerosis due to high cholesterol levels.