What is the primary indication of Methotrexate Sodium?

Methotrexate Sodium is primarily indicated for the management of severe rheumatoid arthritis, a chronic inflammatory disorder that primarily affects joints. Rheumatoid arthritis can cause joint damage and serious disability, and methotrexate works as a disease-modifying antirheumatic drug (DMARD). It helps in slowing down the progression of the disease and alleviates symptoms by suppressing the immune system and reducing inflammation.

In the context of its use, methotrexate can improve quality of life for individuals suffering from severe rheumatoid arthritis, making it an integral part of treatment regimens. The drug is effective in altering the course of the disease, potentially preventing joint damage and decreasing the need for corticosteroids and other more potent immunosuppressants.

The other conditions listed, such as hypertension, urinary tract infections, and depression, do not align with the mechanism and clinical applications of methotrexate, which focuses on autoimmune and inflammatory conditions rather than these other conditions.