What potential side effect is associated with SSRIs?

Serotonin syndrome is a potential side effect associated with selective serotonin reuptake inhibitors (SSRIs) due to the way these medications affect serotonin levels in the brain. SSRIs increase the availability of serotonin by inhibiting its reuptake into presynaptic neurons. While this therapeutic effect can relieve symptoms of depression and anxiety, excessive serotonin activity can lead to serotonin syndrome, a potentially life-threatening condition characterized by symptoms such as confusion, agitation, rapid heart rate, dilated pupils, muscle rigidity, and in severe cases, hyperthermia and seizures. Serotonin syndrome often occurs when an SSRI is combined with other medications that also increase serotonin levels, which underlines the importance of monitoring patients closely when they are prescribed these drugs.

While the other options can be associated with SSRIs, they are generally less severe and may occur less frequently compared to the more critical nature of serotonin syndrome.