Which of the following drugs is not classified as controlled?

Vesicare and Januvia are not classified as controlled substances, making the selection of both as the correct answer appropriate. Vesicare (solifenacin) is an anticholinergic medication used for treating overactive bladder, while Januvia (sitagliptin) is an oral antihyperglycemic agent utilized in managing type 2 diabetes. Neither drug has a high potential for abuse or addiction, which is the key criterion for classification as a controlled substance.

In contrast, Calan (verapamil) is a calcium channel blocker used primarily for hypertension and certain types of angina, but it does not fall under controlled substance laws due to its lower abuse potential compared to drugs that are classified as controlled.

The classifications of drugs into controlled substances (such as those listed in schedules I-V) are based on their potential for abuse, dependence, and medical use. Understanding these classifications aids in ensuring safe prescribing and dispensing practices in the pharmacy setting.