Which of the following has a controlled status?

Oxycodone Hydrochloride with Acetaminophen is classified as a controlled substance because it contains oxycodone, which is an opioid analgesic. Opioids are strictly regulated due to their potential for abuse, addiction, and the risk of overdose. The combination with acetaminophen does not lessen the controlled status, as methadone and other similar drugs that have pain-relieving properties are monitored under the Controlled Substances Act.

In contrast, diltiazem hydrochloride, atenolol, and topiramate do not carry the same risks of abuse and addiction associated with opioids, which is why they are not classified as controlled substances. Diltiazem is a calcium channel blocker used primarily for hypertension and angina, atenolol is a beta-blocker for cardiovascular conditions, and topiramate is an anticonvulsant used for epilepsy and migraine prevention. These medications are generally considered safer and have a lower potential for misuse.