Which of the following is a consideration when prescribing tricyclic antidepressants?

When prescribing tricyclic antidepressants (TCAs), one significant consideration is the potential for cardiotoxicity. TCAs can have effects on cardiac conduction and may lead to arrhythmias, especially in patients with pre-existing heart conditions or those who are taking other medications that can affect heart rhythm. Due to their ability to inhibit norepinephrine and serotonin reuptake, these antidepressants can also cause increased heart rate and various cardiovascular effects. This factor necessitates careful monitoring of patients, particularly during the initiation of therapy or when dosages are adjusted.

The other options, while relevant to the overall context of medication management, do not encapsulate the critical risks associated with TCAs as accurately. For example, the onset of effects for TCAs is not immediate and typically takes several weeks, making the option regarding immediate effects less relevant. Dependence is more commonly associated with certain other classes of medications, such as benzodiazepines. Lastly, while TCAs do have therapeutic benefits, they are also known for a range of side effects, contradicting the idea of having minimal side effects. Thus, recognizing the potential for cardiotoxicity is paramount when considering the safe use of tricyclic antidepressants in practice.