Which of the following medications requires a MedGuide?

MedGuides are specialized patient medication guides that are required for certain medications to ensure that patients understand the risks and benefits associated with their use. Accutane, a brand name for isotretinoin, is a powerful medication used primarily for severe acne that hasn't responded to other treatments. It has significant side effects, including severe birth defects if taken during pregnancy, which is why patients must receive detailed information regarding its use.

The requirement of a MedGuide for Accutane helps to inform patients about these serious risks, as well as the importance of adhering to strict guidelines, such as using two forms of birth control while on the drug and undergoing regular pregnancy tests. This level of risk management underscores the necessity for patients to be well-informed, which the MedGuide addresses effectively.

Other medications in the list, such as ibuprofen, amoxicillin, and penicillin, do not carry the same level of serious risks that necessitate a MedGuide. Although they have warnings and side effects, they don’t require specialized distribution of a MedGuide to ensure patient understanding of their risks. Hence, Accutane stands out as the medication that requires a MedGuide due to the critical safety considerations involved in its use.