Which of the following medications is classified as a controlled substance?

Hydrocodone with Acetaminophen is classified as a controlled substance because it contains hydrocodone, an opioid pain reliever. Controlled substances are drugs that have the potential for abuse, dependence, or addiction, and their distribution is strictly regulated by law. Hydrocodone is classified under the scheduling system established by the Controlled Substances Act, which categorizes drugs based on their medical use, potential for abuse, and safety.

In contrast, the other medications listed do not fall under the controlled substance category. Lisinopril is an antihypertensive medication, simvastatin is a statin used to lower cholesterol, and levothyroxine sodium is a thyroid hormone replacement therapy. These drugs are not associated with a high potential for abuse or dependence, which is why they are not classified as controlled substances.